Sodium Hydroxide → 4-(Chloro(4-chlorophenyl)methyl)-1-methylpiperidine
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)O)=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O.[OH-].[Na+]>C1(C)C=CC=CC=1>[Cl:19][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1참가 물질
5
실험 절차
To a solution of 4-chlorophenyl 1-methylpiperidin-4-yl methanol 1.2 g (5.02 mmol) in toluene (5 ml) was added thionyl chloride (0.45 ml) dropwise. The resulting mixture was stirred at room temperature over night. The mixture was then made alkaline with NaOH solution and extracted with ethyl acetate (3×40). The combined organic solution was dried and concentrated to give 1.2 g of desired product.
후처리
- extractionextracted with ethyl acetate (3×40)
- customThe combined organic solution was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-041276996f234298a025d98ae4560f94
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07659395B2
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