N-Iodosuccinimide → 7-Iodo-2-methyl-5H-thiazolo[4,5-c]pyridin-4-one
반응식
[CH3:1][C:2]1[S:3][C:4]2[CH:9]=[CH:8][NH:7][C:6](=[O:10])[C:5]=2[N:11]=1.[I:12]N1C(=O)CCC1=O>C(#N)C>[I:12][C:9]1[C:4]2[S:3][C:2]([CH3:1])=[N:11][C:5]=2[C:6](=[O:10])[NH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
2-Methyl-5H-thiazolo[4,5-c]pyridin-4-one (770 mg, 4.6 mmol) was suspended in 25 ml acetonitrile and N-iodosuccinimide (1.04 g, 4.6 mmol) was added. The reaction mixture was refluxed for 3 hrs. The brown suspension was cooled to 5° C. and stirred for 15 min. The solid was filtered, washed with cold acetonitrile and dried for 1 hour at 50° C. and <30 mbar. The crude product (830 mg, 61%) [MS: m/e=292.9 (M+H+)] was used without any further purification for the next step.
후처리
- temperatureThe reaction mixture was refluxed for 3 hrs
- filtrationThe solid was filtered
- washwashed with cold acetonitrile
- customdried for 1 hour at 50° C.
- customThe crude product (830 mg, 61%) [MS: m/e=292.9 (M+H+)] was used without any further purification for the next step
출처 및 근거
- ORD 기록
- ord-ab41380a4b9b4e1cb3eca0d41b2332df
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07659401B2
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