Citric Acid → 1-Chloro-4-methoxy-5-methyl-2-nitrobenzene
반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CI.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([O:11][CH3:13])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]참가 물질
6
실험 절차
To a stirred solution of 4-chloro-2-methyl-5-nitrophenol (18.8 g, 100 mmol) in DMF (200 ml) was added potassium carbonate (13.8 g, 100 mmol) and methyl iodide (21.3 g, 150 mmol). The mixture was stirred for about two hours at room temperature. 5% Citric acid was added and the mixture was extracted three times with ethyl acetate. The organic phase was washed with brine, dried with sodium sulphate and evaporated under reduced pressure which gave the title compound (20 G, 100%).
후처리
- extractionthe mixture was extracted three times with ethyl acetate
- washThe organic phase was washed with brine
- dry with materialdried with sodium sulphate
- customevaporated under reduced pressure which
출처 및 근거
- ORD 기록
- ord-b9ad01e20d3643a9bdf09246d02b8172
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07659245B2
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