Sodium hydride → 5-Ethynyl-1H-indole

HRID 1443788노트

반응식

HRID 1443788 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]#[C:11]C(C)(O)C)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[H-].[Na+]>C1(C)C=CC=CC=1>[C:10]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][CH:2]=[CH:3]2)#[CH:11]

참가 물질

4

반응물 2

HCID 24758Sodium hydrideHCID 668793284-(1H-indol-5-yl)-2-methyl-but-3-yn-2-ol

생성물 1

HCID 178425855-Ethynyl-1H-indole

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
110 °C

실험 절차

A mixture of 4-(1H-indol-5-yl)-2-methyl-but-3-yn-2-ol (6.6 g, 33.1 mmol), sodiumhydride, 60% in mineral oil (0.13 g, 3.3 mmol) and anhydrous toluene (100 ml) was stirred for 5 hours at 110° C. The crude mixture was evaporated. Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound. Yield 3.44 g (74%). Oil.

후처리

  1. customThe crude mixture was evaporated

출처 및 근거

ORD 기록
ord-c51de70d132d4025825b45ef3f50f0c6
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662812B2

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