Lithium Hydroxide → [5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

HRID 1443998노트

반응식

HRID 1443998 반응식
C[O:2][C:3](=[O:26])[CH2:4][S:5][C:6]1[CH:11]=[N:10][C:9]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:17]=2[Cl:23])(=[O:15])=[O:14])=[C:8]([O:24][CH3:25])[N:7]=1.[OH-].[Li+]>CO.O>[Cl:23][C:17]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:16]=1[S:13]([NH:12][C:9]1[N:10]=[CH:11][C:6]([S:5][CH2:4][C:3]([OH:26])=[O:2])=[N:7][C:8]=1[O:24][CH3:25])(=[O:15])=[O:14]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 58597364[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester

생성물 1

HCID 59168222[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester (Example 82) (0.1 g) and lithium hydroxide (0.04 g) in methanol (5 mL) and water (1 mL) was stirred at room temperature. After 2 h, the mixture was evaporated and saturated aqueous citric acid (5 mL) added. The white solid was collected, washed with water and dried. Yield 0.07 g.

후처리

  1. customthe mixture was evaporated
  2. additionsaturated aqueous citric acid (5 mL) added
  3. customThe white solid was collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-906e0b1595c0450b828a2ddb0d1a53a6
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662825B2

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