tert-Butyl acetate → (6-{4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl)-5-methyl-pyridin-3-yl)-acetic acid tert-butyl ester

반응식

C1([N-]C2CCCCC2)CCCCC1.[Li+].[C:15]([O:19][C:20](=[O:22])[CH3:21])([CH3:18])([CH3:17])[CH3:16].Br[C:24]1[CH:25]=[C:26]([CH3:56])[C:27]([N:30]2[CH2:35][CH2:34][N:33]([C:36]3[CH:41]=[C:40]([C:42]4[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=4)[N:39]=[C:38]([N:49]4[CH2:53][CH2:52][CH2:51][C@H:50]4[CH3:54])[N:37]=3)[C@H:32]([CH3:55])[CH2:31]2)=[N:28][CH:29]=1.CC(P(C(C)(C)C)C(C)(C)C)(C)C>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:15]([O:19][C:20](=[O:22])[CH2:21][C:24]1[CH:29]=[N:28][C:27]([N:30]2[CH2:35][CH2:34][N:33]([C:36]3[CH:41]=[C:40]([C:42]4[CH:43]=[CH:44][C:45]([F:48])=[CH:46][CH:47]=4)[N:39]=[C:38]([N:49]4[CH2:53][CH2:52][CH2:51][C@H:50]4[CH3:54])[N:37]=3)[C@H:32]([CH3:55])[CH2:31]2)=[C:26]([CH3:56])[CH:25]=1)([CH3:18])([CH3:17])[CH3:16]