Sodium Hydroxide → 5-Phenylfuran-2-carboxylic acid

HRID 1444203노트

반응식

HRID 1444203 반응식
[OH-].[Na+].C[O:4][C:5]([C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)=[O:6]>O.CO>[C:12]1([C:9]2[O:8][C:7]([C:5]([OH:6])=[O:4])=[CH:11][CH:10]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 11275689Methyl 5-phenylfuran-2-carboxylate

생성물 1

HCID 7362555-Phenylfuran-2-carboxylic acid수율 97.9%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of sodium hydroxide (200 mg) in water (5 ml) was added to a stirred solution of 5-phenyl-furan-2-carboxylic acid methyl ester (7) (384 mg, 1.90 mmoles) in methanol (20 ml) and the mixture was stirred at room temperature for 4 hours. The solvent was evaporated and the residue was diluted with water (10 ml) and acidified to pH=2 with 1 M aqueous hydrochloric acid. The precipitate was collected, washed with water and the residue was triturated with cyclohexane to afford (8) (350 mg) as a white solid. LC/MS System A; Rt=3.89 mins.

후처리

  1. customThe solvent was evaporated
  2. additionthe residue was diluted with water (10 ml)
  3. customThe precipitate was collected
  4. washwashed with water
  5. customthe residue was triturated with cyclohexane

출처 및 근거

ORD 기록
ord-eb9ea6368dcc41dd96d31788d0675df0
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662839B2

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