3-Aminocinnamic acid ethyl ester → 3-(3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

HRID 1444274

반응식

HRID 1444274 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:18][C:19](=[O:29])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:29])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][C:13]([C:11]2[O:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:9][CH:10]=2)=[O:15])[CH:23]=1)[CH3:17]

참가 물질

3

반응물 2

HCID 978253-Aminocinnamic acid ethyl esterHCID 7362565-(3-Chlorophenyl)furan-2-carboxylic acid

생성물 1

HCID 684907963-(3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenyl)-acrylic acid ethyl ester

실험 절차

Carboxylic acid (65) (58 mg, 0.26 mmol) was coupled to ethyl ester (60) (50 mg, 0.26 mmol) using Method C. The crude residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.

후처리

  1. customThe crude residue was purified by column chromatography
  2. washeluting with a stepped gradient of 10-15% EtOAc in heptane

출처 및 근거

ORD 기록
ord-57635100a5f04ce58e90eeb35e11ad1a
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662839B2

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