Potassium Carbonate → 4-Piperidinopiperidine-1-carbonyl chloride

HRID 1444683

반응식

HRID 1444683 반응식
Cl.[N:2]1([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([Cl:16])=[O:15])[CH2:10][CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:2]1([CH:8]2[CH2:9][CH2:10][N:11]([C:14]([Cl:16])=[O:15])[CH2:12][CH2:13]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 116375531-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

생성물 1

HCID 98133754-Piperidinopiperidine-1-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan

후처리

  1. filtrationThe solution was filtered
  2. washthe cake washed with 10 ml of methylene chloride
  3. additionThe solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride)
  4. customsuch for the preparation of Irinotecan

출처 및 근거

ORD 기록
ord-8b865cb372234e82bd5519d0c0b4537c
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662964B2

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