Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Piperidinopiperidine-1-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride | HCID 11637553 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Piperidinopiperidine-1-carbonyl chloride | HCID 9813375 | — |
반응 단계
[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662964B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-8b865cb372234e82bd5519d0c0b4537c |
| 출처 메모 | uspto-grants-2010_02 |