Sodium Hydroxide → Sodium {2-[6-(4-methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetate
반응식
C[O:2][C:3](=[O:27])[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([C:17]3[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[OH-].[Na+:29]>CO.O1CCCC1>[CH3:26][S:23]([C:20]1[CH:19]=[CH:18][C:17]([C:14]2[N:13]=[CH:12][C:11]([C:7]3[O:8][C:9]([CH3:10])=[C:5]([CH2:4][C:3]([O-:27])=[O:2])[N:6]=3)=[CH:16][CH:15]=2)=[CH:22][CH:21]=1)(=[O:24])=[O:25].[Na+:29]참가 물질
4
실험 절차
To a stirring solution of {2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester (See Intermediate 19) (1.0 mmol) in 1:1 methanol/tetrahydrofuran (0.10M), add 2N sodium hydroxide (1.2 mmol) and heat to reflux for 1 hour. After this time, concentrate the reaction in vacuo. Wash the resulting solid twice with dichloromethane to rinse away any impurities. MS (nme): 373.3 (M+1)