Dichloromethane → 3-[2-(4-Bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde

HRID 1445766

반응식

HRID 1445766 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:21])=[C:11]([CH2:13][CH2:14][CH:15]3SCCCS3)[N:12]=2)=[CH:4][CH:3]=1.C1C[O:25]CC1.C(Cl)Cl>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:21])=[C:11]([CH2:13][CH2:14][CH:15]=[O:25])[N:12]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 860966842-(4-Bromo-phenyl)-4-(2-[1,3]dithian-2-yl-ethyl)-5-methyl-oxazole

생성물 1

HCID 860966863-[2-(4-Bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde수율 86%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Add HgClO4.4H2O (1.49 g, 4.00 mmol) to a solution of 2-(4-bromo-phenyl)-4-(2-[1,3]dithian-2-yl-ethyl)-5-methyl-oxazole (0.672 g, 1.75 mmol) in 1:1 THF:CH2Cl2 (16 mL) and water (1.6 mL). After 6 hours, filter and wash the solids with dichloromethane. Concentrate to give 3-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde (0.445 g, 86%). MS (m/e): 294 (M+1).

후처리

  1. filtrationfilter
  2. washwash the solids with dichloromethane
  3. concentrationConcentrate

출처 및 근거

ORD 기록
ord-581f60603cc340ffa47786629ed187a7
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666871B2

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