Hydrochloric Acid → (+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine dihydrochloride salt

HRID 1445794노트

반응식

HRID 1445794 반응식
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:10]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][CH:15]=2)[O:12][CH:13]=1.[ClH:26]>ClCCl.C(OCC)C>[ClH:26].[ClH:26].[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:10]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][CH:15]=2)[O:12][CH:13]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 11537304(+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine

생성물 1

HCID 69468390(+/-)-3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine dihydrochloride salt

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

Dissolve 3-{4-[4-(2-Methyl-piperidin-1-ylmethyl)-oxazol-2-yl]-phenyl}-pyridine (See Example 22) in minimal dichloromethane and add 1M hydrochloric acid in diethyl ether until the solution is cloudy. Add hexane and concentrate in vacuo to yield the titled compound. MS (m/e): 334.1 (M+1)

후처리

  1. concentrationAdd hexane and concentrate in vacuo

출처 및 근거

ORD 기록
ord-a42a2ab629364aa1829b71fa13e3ca2d
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666871B2

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