Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → (2-Methyl-1H-indol-4-yloxy)-acetic acid benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzyl bromoacetate | HCID 62576 | — |
| 반응물 | 4-Hydroxy-2-methylindole | HCID 590225 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | (2-Methyl-1H-indol-4-yloxy)-acetic acid benzyl ester | HCID 58765424 | — |
반응 단계
A mixture of 4-hydroxy-2-methylindole (3.0 g, 0.02 mole), bromo-acetic acid benzyl ester (4.6 g, 0.02 mole), potassium carbonate (2.8 g, 0.02 mole) in acetone was refluxed for 48 h. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (10:1 Hex:EtOAc) to afford intermediate (2). Yield: 3.5 g, 58%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07666898B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-af9a5eb9069141e4a752b31f69239149 |
| 출처 메모 | uspto-grants-2010_02 |