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Diisopropylethylamine → 2-{4-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]isoxazol-5-yl}pyridine

HRID 1446265
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HRID 1446265 반응식
[NH:1]1[CH2:5][CH2:4][CH:3]([C:6]2[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH2:2]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C.[N:43]1[CH:48]=[CH:47][CH:46]=[CH:45][C:44]=1[C:49]1[O:53][N:52]=[CH:51][C:50]=1[C:54](O)=[O:55]>CN(C=O)C>[N:8]1[CH:9]=[CH:10][CH:11]=[C:6]([CH:3]2[CH2:4][CH2:5][N:1]([C:54]([C:50]3[CH:51]=[N:52][O:53][C:49]=3[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][N:43]=3)=[O:55])[CH2:2]2)[CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 36136513-(Pyrrolidin-3-yl)pyridineHCID 223090705-(Pyridin-2-yl)-1,2-oxazole-4-carboxylic acid

생성물 1

HCID 591702042-{4-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]isoxazol-5-yl}pyridine

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A solution of 3-pyrrolidin-3-yl-pyridine (15 mg, 0.1 mmol), TBTU (48 mg, 0.15 mmol, 1.5 equ.) and N-ethyl-N-isopropylpropan-2-amine (17 μL, 0.1 mmol) in DMF (0.6 mL) was added to 5-pyridin-2-ylisoxazole-4-carboxylic acid (19 mg, 0.1 mmol) and the reaction mixture was stirred at rt for 2 h. The solvent was evaporated and the crude product was purified by RP-HPLC. After evaporation of the solvents from the pure fractions, the residue was dissolved in chloroform and washed with diluted NaOH to provide the neutral compound in the organic phase that was dried (Na2SO4) and evaporated and dried in vacuum to yield the title compound as (12 mg). MS (ESI, pos. ion) m/z calcd for C18H16N4O2: 320.1273, found 320.1273.

후처리

  1. customThe solvent was evaporated
  2. customthe crude product was purified by RP-HPLC
  3. customAfter evaporation of the solvents from the pure fractions
  4. dissolutionthe residue was dissolved in chloroform
  5. washwashed with diluted NaOH
  6. customto provide the neutral compound in the organic phase that
  7. dry with materialwas dried (Na2SO4)
  8. customevaporated
  9. customdried in vacuum

출처 및 근거

ORD 기록
ord-fb35fa38ba3241e198ec71e259b59213
출처 데이터셋
uspto-grants-2010_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07666888B2

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