Sodium borohydride → 5-Methyl-3-phenylhexan-2-ol

HRID 1446403노트

반응식

HRID 1446403 반응식
[CH3:1][CH:2]([CH3:14])[CH2:3][CH:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](=[O:7])[CH3:6].[BH4-].[Na+]>CO>[CH3:1][CH:2]([CH3:14])[CH2:3][CH:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH:5]([OH:7])[CH3:6]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 131565125-Methyl-3-phenylhexan-2-one

생성물 1

HCID 222704255-Methyl-3-phenylhexan-2-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 66 mg (0.345 mmol) of 5-methyl-3-phenyl-2-hexanone in 1 mL MeOH was treated with 16 mg sodium borohydride. After 1.5 h, the reaction was quenched with 1.2 N HCl and concentrated. The residue was partitioned between EtOAc and water. The organic layer was washed with brine, dried and concentrated to yield the crude title compound which was used without purification. 1H NMR: (500 MHz, CDCl3): δ 0.88 (2d, 6H), 1.0-1.8 (m, 4H), 1.2 (d, 3H), 2.64 (m, 1H), 3.9 (m, 1H), 7.2-7.4 (m, 5H).

후처리

  1. customthe reaction was quenched with 1.2 N HCl
  2. concentrationconcentrated
  3. customThe residue was partitioned between EtOAc and water
  4. washThe organic layer was washed with brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-accfadecf8e942e5a1525fdd9979419f
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07667053B2

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