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Lithium hydroxide, monohydrate → (E)-N-indan-1-yl-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylamide

HRID 1446446
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HRID 1446446 반응식
O.[OH-].[Li+].[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[N:14]1[CH:18]=[C:17]([CH3:19])[N:16]=[CH:15]1)[CH:9]=O.C(OP([CH2:28][C:29](=[O:40])[NH:30][CH:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH2:33][CH2:32]1)(=O)OCC)C>C1COCC1>[CH:31]1([NH:30][C:29](=[O:40])/[CH:28]=[CH:9]/[C:8]2[CH:11]=[CH:12][C:13]([N:14]3[CH:18]=[C:17]([CH3:19])[N:16]=[CH:15]3)=[C:6]([O:5][CH3:4])[CH:7]=2)[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH2:33][CH2:32]1
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참가 물질

5

반응물 3

HCID 168937Lithium hydroxide, monohydrateHCID 272824453-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehydeHCID 86602465(Indan-1-ylcarbamoylmethyl)phosphonic acid diethyl ester

생성물 1

HCID 59170837(E)-N-indan-1-yl-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylamide수율 36.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

실험 절차

Lithium hydroxide monohydrate (9 mg) was added to a THF (2 mL) solution of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (21 mg) and indan-1-ylcarbamoylmethylphosphonic acid diethyl ester (30 mg) obtained above, and the reaction solution was agitated at room temperature overnight. After the reaction mixture was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (Carrier: Chromatorex™ NH, elution solvent:hexane-ethyl acetate system), and 13 mg of the title compound was obtained.

후처리

  1. customobtained above, and the reaction solution
  2. concentrationAfter the reaction mixture was concentrated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (Carrier: Chromatorex™ NH, elution solvent:hexane-ethyl acetate system)

출처 및 근거

ORD 기록
ord-e43eec730fda458ba850ba2feed53882
출처 데이터셋
uspto-grants-2010_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07667041B2

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