N-bromobutanimide → 3-Bromo-7-thiazol-2-yl-imidazo[1,2-a]pyridine
반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][N:9]2[CH:12]=[CH:13][N:14]=[C:8]2[CH:7]=1.C1C(=O)N([Br:22])C(=O)C1>C(O)C.ClCCl>[Br:22][C:12]1[N:9]2[CH:10]=[CH:11][C:6]([C:2]3[S:1][CH:5]=[CH:4][N:3]=3)=[CH:7][C:8]2=[N:14][CH:13]=1참가 물질
5
실험 절차
Dissolve 7-thiazol-2-yl-imidazo[1,2-a]pyridine (1.14 g, 5.66 mmol) in 25 mL absolute ethanol, then add NBS (1.0 g, 5.66 mmol), stir the mixture at room temperature for 15 minutes, dilute with 35 mL dichloromethane and apply to a 10 g SCX Mega Bond-Elut™ cartridge (Varian) pre-washed with 150 mL 1:1 CH2Cl2:MeOH. Wash the SCX cartridge with 300 mL 1:1 CH2Cl2:MeOH, elute with 150 mL CH2Cl2:2 M NH3-MeOH, and concentrate the eluates and dry to provide 1.07 g (67%) of the title compound as a tan solid. MS (ES) 280, 282.
후처리
- washpre-washed with 150 mL 1:1 CH2Cl2
- washWash the SCX cartridge with 300 mL 1:1 CH2Cl2
- washMeOH, elute with 150 mL CH2Cl2
- concentration2 M NH3-MeOH, and concentrate the eluates
- customdry
출처 및 근거
- ORD 기록
- ord-21a2d8e681ab4c06a3299f810d10953b
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07666879B2
반응 노트
불러오는 중…