Chloroacetaldehyde → 7-Iodoimidazo[1,2-a]pyridine

HRID 1446679노트

반응식

HRID 1446679 반응식
[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.Cl[CH2:10][CH:11]=O>C(O)C>[I:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:10]=[CH:11][N:8]=[C:4]2[CH:3]=1

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 226075514-Iodopyridin-2-amine

생성물 1

HCID 532499347-Iodoimidazo[1,2-a]pyridine수율 32%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
83 °C

실험 절차

Combine 4-iodo-pyridin-2-ylamine (4.00 g, 18.18 mmol) and chloroacetaldehyde (2.77 mL, 21.82 mmol) in ethanol (40 mL). Attach a reflux condenser, and heat the mixture to 83° C., stir overnight (15 hours), and cool to room temperature. Filter the resulting solution to yield the product as a tan solid (1.40 g, 32%). MS(ES), m/z 245 (M+1)

후처리

  1. temperaturecool to room temperature
  2. filtrationFilter the resulting solution

출처 및 근거

ORD 기록
ord-076a4249e2d247c3a9ff489d149b2d22
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666879B2

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