1H-Imidazole-4-carbaldehyde → Triphenylphosphine Oxide

HRID 1446805노트

반응식

HRID 1446805 반응식
[C:1]1([P:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=C(C)C(OC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=C(C=[O:32])N=C1>C(O)C>[C:1]1([P:7](=[O:32])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 764281H-Imidazole-4-carbaldehydeHCID 10569721Methyl 2-(triphenyl-lambda~5~-phosphanylidene)propanoate

생성물 1

HCID 13097Triphenylphosphine Oxide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 0.961 g (10 mmol) of methyl 2-(triphenylphosphoranylidene)propionate [H. J. Bestmann and H. Schulz, Angew. Chem., 73, 27 (1961)] and 3.48 g (10 mmol) of imidazole-4-carboxaldehyde [F. L. Pyman, J. Chem. Soc., 186 (1916)] in 50 ml of absolute ethanol is stirred at room temperature for seven days. At the end of this time, the ethanol is removed in vacuo and the desired product is isolated free of triphenylphosphine oxide by chromatography on silica gel. The product thus obtained is a mixture of E and Z olefin isomers.

후처리

  1. customAt the end of this time, the ethanol is removed in vacuo

출처 및 근거

ORD 기록
ord-1fc85ae81581434fba6c6d170ce17949
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04313948

반응 노트

불러오는 중…