2-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide → 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide

HRID 1446826노트

반응식

HRID 1446826 반응식
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH:17](SC)[C:18]([NH2:20])=[O:19]>[Ni].C(O)C.CN(C)C=O>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH2:17][C:18]([NH2:20])=[O:19]

참가 물질

5

반응물 1

HCID 670799562-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide

생성물 1

HCID 178767402-AMino-3-benzoyl-5-chlorobenzeneacetaMide

시약·촉매·용매 3

HCID 935Nickel촉매HCID 702Ethanol용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 21.34 g (0.0639 mole) of 2-amino-3-benzoyl-5-chloro-α-(methylthio)-phenylacetamide and excess Raney nickel in a mixture of 900 ml of absolute ethanol and 200 ml of dimethylformamide was stirred at room temperature for 45 min. The mixture was filtered through celite to remove the Raney nickel. The solvent was removed in vacuo to give a yellow solid which when recrystallized melted at 213.5°-215.0° C.(d).

후처리

  1. filtrationThe mixture was filtered through celite
  2. customto remove the Raney nickel
  3. customThe solvent was removed in vacuo
  4. customto give a yellow solid which when
  5. customrecrystallized melted at 213.5°-215.0° C.(d)

출처 및 근거

ORD 기록
ord-3d4b8b6afa974027b6a4a17c4d914055
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04313949

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