HCID 20552958, 화합물 → HCID 70542001, 화합물
반응식
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH:16](SC)[C:17]([NH:19][CH3:20])=[O:18]>O1CCCC1.[Ni]>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH:19][CH3:20])=[O:18]참가 물질
4
실험 절차
A solution of 22.5 g (0.072 mol) of 2-amino-3-benzoyl-α-(methylthio)-N-methylphenylacetamide in 400 ml of tetrahydrofuran was treated with 160 g of wet Raney nickel (washed 3 times with water and 3 times with tetrahydrofuran) for 10 minutes. The mixture was filtered and the filtrate was concentrated. The residue was crystallized from isopropyl alcohol to give 17.2 g (89%) of yellow needles, m.p. 145°-146° C.
후처리
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue was crystallized from isopropyl alcohol
출처 및 근거
- ORD 기록
- ord-61870cab486b429da7764d0a2d31b4d8
- 출처 데이터셋
- uspto-grants-1982_02
- 특허 번호
- US04313949
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