Thionyl Chloride → 2-{4-[N-Methyl-N-(5-chloro-2-benzoxazolyl)amino]phenoxy}propionyl chloride

HRID 1446886노트

반응식

HRID 1446886 반응식
[CH3:1][N:2]([C:13]1[CH:24]=[CH:23][C:16]([O:17][CH:18]([CH3:22])[C:19](O)=[O:20])=[CH:15][CH:14]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:6]=2[N:7]=1.S(Cl)([Cl:27])=O>C(Cl)(Cl)Cl>[CH3:1][N:2]([C:13]1[CH:24]=[CH:23][C:16]([O:17][CH:18]([CH3:22])[C:19]([Cl:27])=[O:20])=[CH:15][CH:14]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 133148242-{4-[N-Methyl-N-(5-chloro-2-benzoxazolyl)amino]phenoxy}propionic acid

생성물 1

HCID 205535162-{4-[N-Methyl-N-(5-chloro-2-benzoxazolyl)amino]phenoxy}propionyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 2-{4-[N-methyl-N-(5-chloro-2-benzoxazolyl)amino]phenoxy}propionic acid (3.0 g, 0.0087 mole; see Example 9), thionyl chloride (0.76 ml, 0.01 mole) and chloroform (25 ml) was heated under reflux for a period of 3 hours. The reaction mixture was cooled and the solvent and excess thionyl chloride was removed by distillation under reduced pressure to give the title compound.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for a period of 3 hours
  3. temperatureThe reaction mixture was cooled
  4. customthe solvent and excess thionyl chloride was removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-e6c132bf0d2f4d348c05bbfeaeaf403f
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04314065

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