Ethyl 2-chloropropionate → Ethyl 2-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propanoate

HRID 1446899노트

반응식

HRID 1446899 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.Cl[CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([O:14][CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:12][CH:13]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 10807Ethyl 2-chloropropionateHCID 11430Potassium CarbonateHCID 170230p-(4-(Trifluoromethyl)phenoxy)phenol

생성물 1

HCID 631921Ethyl 2-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propanoate수율 54%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A solution of 73.5 g of 4-(4-trifluoromethylphenoxy)phenol and 49.2 g of ethyl α-chloropropionate and 100 g of potassium carbonate were added to 100 ml of methyl ethyl ketone, and the mixture was heated. With stirring, the reaction was performed for 10 hours at the reflux temperature (80° to 85° C.). Inorganic salts were separated from the reaction product by filtration. The filtrate was evaporated and dried. The resulting ester was extracted with chloroform, and washed with water. The chloroform was distilled off to afford 55 g of the final product (yield: 54%). The final product had a boiling point of 176° to 185° C./3 mmHg.

후처리

  1. temperaturethe mixture was heated
  2. customInorganic salts were separated from the reaction product by filtration
  3. customThe filtrate was evaporated
  4. customdried
  5. extractionThe resulting ester was extracted with chloroform
  6. washwashed with water
  7. distillationThe chloroform was distilled off

출처 및 근거

ORD 기록
ord-61e0b408a9a845d2b5bb1b6073bfc49e
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04314069

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