1,2,3,4-Tetrahydroisoquinoline → 2-Acetyl-1,2,3,4-tetrahydroisoquinoline

HRID 1447110노트

반응식

HRID 1447110 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)(=[O:13])[CH3:12]

참가 물질

3

반응물 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 7918Acetic Anhydride

생성물 1

HCID 6002152-Acetyl-1,2,3,4-tetrahydroisoquinoline

실험 절차

A mixture of 100 g. (0.75 mole) 1,2,3,4-tetrahydroisoquinoline and 150 ml. acetic anhydride was stirred at ambient temperature for 24 hours and then concentrated to dryness at reduced pressure. The residual liquid was dissolved in methylene chloride and solid potassium carbonate was added to neutralize the solution. The excess potassium carbonate was removed by filtration and the filtrate was concentrated to dryness at reduced pressure to afford 2-acetyl-1,2,3,4-tetrahydroisoquinoline as a yellow liquid.

후처리

  1. additionA mixture of 100 g
  2. concentrationconcentrated to dryness at reduced pressure
  3. dissolutionThe residual liquid was dissolved in methylene chloride
  4. additionsolid potassium carbonate was added
  5. customThe excess potassium carbonate was removed by filtration
  6. concentrationthe filtrate was concentrated to dryness at reduced pressure

출처 및 근거

ORD 기록
ord-c79b68032fbe4b7eb3ea1a3bcdf03850
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04315935

반응 노트

불러오는 중…