Acetic Acid → Aptazapine

HRID 1447399노트

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HRID 1447399 반응식
[CH3:1][N:2]1[C:19](=O)[C:18](=O)[N:5]2[C:6]3[CH:17]=[CH:16][CH:15]=[CH:14][C:7]=3[CH2:8][N:9]3[CH:13]=[CH:12][CH:11]=[C:10]3[CH:4]2[CH2:3]1.C(O)(=O)C>O1CCCC1.B#B>[CH3:1][N:2]1[CH2:19][CH2:18][N:5]2[C:6]3[CH:17]=[CH:16][CH:15]=[CH:14][C:7]=3[CH2:8][N:9]3[CH:13]=[CH:12][CH:11]=[C:10]3[CH:4]2[CH2:3]1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 128377152-methyl-3,4-dioxo-1,2,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine

생성물 1

HCID 51355Aptazapine

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 6328200Diboron용매

실험 절차

To the suspension of 12.8 g of 2-methyl-3,4-dioxo-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine in 460 ml of tetrahydrofuran, 200 ml of 1-molar diborane in tetrahydrofuran are added while stirring and cooling with ice. The mixture is refluxed for one hour, again cooled and combined with 25 ml of acetic acid. It is evaporated, the residue taken up in 50 ml of 30% aqueous sodium hydroxide and the mixture extracted with methylene chloride. The extract is dried, evaporated, the residue dissolved in diethyl ether, the solution filtered and the filtrate evaporated, to yield the 2-methyl-1,3,4,14b-tetrahydro-10H--pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine.

후처리

  1. additionare added
  2. temperaturecooling with ice
  3. temperatureThe mixture is refluxed for one hour
  4. temperatureagain cooled
  5. customIt is evaporated
  6. extractionthe mixture extracted with methylene chloride
  7. customThe extract is dried
  8. customevaporated
  9. dissolutionthe residue dissolved in diethyl ether
  10. filtrationthe solution filtered
  11. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-d76781500de2432aae5c7fd6185775b0
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04316900

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