Chloroform → Imidazo(1,2-a)pyridine

HRID 1447613노트

반응식

HRID 1447613 반응식
N[C:2]1[N:6]2[CH:7]=[C:8](SC3C=CC=CC=3)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.C(Cl)(Cl)Cl.COC(Cl)=O>C(N(CC)CC)C>[N:4]1[CH:3]=[CH:2][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 6586Methyl chloroformateHCID 53813641HCID 53813641, 화합물

생성물 1

HCID 78960Imidazo(1,2-a)pyridine

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A solution of 1.0 g. of 3-amino-6-(phenylthio) imidazo [1,2-a] pyridine in 25 ml. of chloroform containing 0.401 g. of triethyl amine is treated dropwise with 0.378 g. of methylchloroformate. The reaction mixture is stirred for 3 hours at room temperature. The chloroform is removed in vacuo and the residue is triturated with water. The solids are collected by filtration, washed well with water and dried. Recrystallization from dimethylformamide-ethane yields pure 3-(methoxycarbonylamino) 6-phenylthio) imidazo [1,2-a] pyridine m.p. 211°-215° C.

후처리

  1. customThe chloroform is removed in vacuo
  2. customthe residue is triturated with water
  3. filtrationThe solids are collected by filtration
  4. washwashed well with water
  5. customdried
  6. customRecrystallization from dimethylformamide-ethane

출처 및 근거

ORD 기록
ord-52d58b88a6cd4441b8d01a1b74a867d1
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04177274

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