Water → N,N'-bis(phthalimido)oxamide N-methyl-2-pyrrolidone

HRID 1447748

반응식

HRID 1447748 반응식
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[C:12]([NH:18][NH2:19])(=[O:17])[C:13]([NH:15][NH2:16])=[O:14].[CH3:20][N:21]1[CH2:25][CH2:24][CH2:23][C:22]1=[O:26].[OH2:27]>C1(C)C=CC=CC=1>[C:22]1(=[O:26])[N:16]([NH:15][C:13]([C:12]([NH:18][N:19]2[C:1](=[O:11])[C:2]3=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]3[C:4]2=[O:5])=[O:17])=[O:14])[C:9](=[O:27])[C:10]2=[CH:2][CH:1]=[CH:25][CH:24]=[C:23]12.[CH3:20][N:21]1[CH2:9][CH2:10][CH2:2][C:1]1=[O:6]

참가 물질

6

반응물 4

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 13387N-methyl-2-pyrrolidoneHCID 13826Oxalic acid, dihydrazide

생성물 1

HCID 70604243N,N'-bis(phthalimido)oxamide N-methyl-2-pyrrolidone

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Two moles of phthalic anhydride (296 g.) and one mole of oxalic dihydrazide (118 g.) in 500 ml. N-methyl-2-pyrrolidone and 500 ml. toluene were heated at reflux until two moles of water were removed (about two hours). The mixture was diluted with benzene and filtered. After washing with benzene, the white product was dried to constant weight at 50° C. giving an essentially quantitative yield of N,N'-bis(phthalimido)oxamide-N-methyl-2-pyrrolidone 1:2 complex.

후처리

  1. customwere removed (about two hours)
  2. additionThe mixture was diluted with benzene
  3. filtrationfiltered
  4. washAfter washing with benzene
  5. customthe white product was dried to constant weight at 50° C.

출처 및 근거

ORD 기록
ord-526c9df1962348b5a18969ed43d1a994
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178280

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