Diethylamine → N,N-Diethyl-2-isopropyl-5-methylcyclohexanecarboxamide

HRID 1447843

반응식

[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10]([OH:12])=O)[CH2:2]1.S(Cl)(Cl)=O.C1(C)CCC(C(C)C)C(C(Cl)=O)C1.[CH2:31]([NH:33][CH2:34][CH3:35])[CH3:32].[OH-].[Na+]>>[CH2:31]([N:33]([CH2:34][CH3:35])[C:10]([CH:3]1[CH:4]([CH:7]([CH3:8])[CH3:9])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:12])[CH3:32]

참가 물질

반응물 5

HCID 8021Diethylamine

HCID 14798Sodium Hydroxide

HCID 24386Thionyl Chloride

HCID 97896p-Menthane-3-carboxylic acid

HCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

생성물 1

HCID 93591N,N-Diethyl-2-isopropyl-5-methylcyclohexanecarboxamide

실험 절차

Following the procedure of Example 5, p-menthane-3-carboxylic acid (1.84 g.) was reacted with thionyl chloride and the p-menth-3-oyl chloride then reacted with diethylamine (0.74 g.) in the presence of sodium hydroxide (0.4 g.). The product N,N-diethyl-p-menthane-3-carboxamide was recovered.

후처리

customThe product N,N-diethyl-p-menthane-3-carboxamide was recovered

출처 및 근거

ORD 기록: ord-90ce00b551b240ffa32aac7cf212334c
출처 데이터셋: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04178459

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