Hydrochloric Acid → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

HRID 1447859노트

반응식

HRID 1447859 반응식
[Na+].[F:2][C:3]([F:23])([F:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([O-:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.Cl>C(Cl)Cl>[F:22][C:3]([F:2])([F:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

생성물 1

HCID 103353477-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 0.70 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt, 25 ml. of methylene chloride and 10 ml. of 1 N hydrochloric acid is stirred overnight. The solid which forms is collected by filtration. The filtrate is evaporated to produce more solid. The solids are combined and recrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

후처리

  1. additionA mixture of 0.70 g
  2. filtrationThe solid which forms is collected by filtration
  3. customThe filtrate is evaporated
  4. customto produce more solid
  5. customrecrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

출처 및 근거

ORD 기록
ord-b271db2ed96b4fb7b418664539371e6e
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178449

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