Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

HRID 1447863노트

반응식

HRID 1447863 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:20][N:18]([CH3:19])[CH:17]=[C:10]([CH3:11])[C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=1)=[O:12]

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 137064Propiophenone, 3'-(trifluoromethyl)

생성물 1

HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

실험 절차

A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.

후처리

  1. additionA mixture of 25 g
  2. customevaporated to an oil
  3. dissolutionThe oil is dissolved in hexane

출처 및 근거

ORD 기록
ord-f3127b22e1ac4643be4bf18e9fe40f1d
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178449

반응 노트

불러오는 중…