3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

HRID 1447882

반응식

HRID 1447882 반응식
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[C:23](C#N)=[C:22]([C:26]#[N:27])[NH:21][N:20]=1>C(O)(=O)C>[C:19]([C:23]1[C:22]([C:26]#[N:27])=[N:21][N:20]2[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:17]=12)#[N:18]

참가 물질

4

반응물 2

HCID 3388303-amino-1H-pyrazole-4,5-dicarbonitrileHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

생성물 1

HCID 113704003-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is treated with trifluoroacetic anhydride to give the product of the example. cl EXAMPLE 44

후처리

  1. additionA mixture of 4.86 g
  2. customthe solvent removed under reduced pressure
  3. additionThe residue is treated with trifluoroacetic anhydride
  4. customto give the product of the example

출처 및 근거

ORD 기록
ord-3be5e32ab22c44608da2087ba1faac10
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178449

연결된 노트

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