반응식
P(Cl)(Cl)(Cl)=O.[F:6][C:7]([F:24])([F:23])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[N:19]3[N:20]=[CH:21][CH:22]=[C:18]3[N:17]=[CH:16][CH:15]=2)[CH:9]=1.CN(C)[CH:27]=[O:28]>>[F:24][C:7]([F:23])([F:6])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[N:19]3[N:20]=[CH:21][C:22]([CH:27]=[O:28])=[C:18]3[N:17]=[CH:16][CH:15]=2)[CH:9]=1참가 물질
4
실험 절차
Five millimeters of phosphorus oxychloride is added dropwise to an ice cooled solution of 25 ml. of dimethylformamide and when this is complete 5.26 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine is added and the reaction mixture is heated on a steam bath for one hour. This is poured onto ice and made strongly basic to yield the desired compound, recovered by subsequent filtration, m.p. 168°-170° C.
후처리
- temperaturethe reaction mixture is heated on a steam bath for one hour
- additionThis is poured onto ice
출처 및 근거
- ORD 기록
- ord-3772e82fef434e408a4b113c69d04f20
- 출처 데이터셋
- uspto-grants-1979_12
- 특허 번호
- US04178449
연결된 노트
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