Ubenimex → L-Leucine

HRID 1448156

반응식

HRID 1448156 반응식
[CH3:1][CH:2]([CH2:4][C@H:5]([NH:9]C([C@@H](O)[C@H](N)CC1C=CC=CC=1)=O)[C:6]([OH:8])=[O:7])[CH3:3]>Cl>[NH2:9][C@H:5]([C:6]([OH:8])=[O:7])[CH2:4][CH:2]([CH3:3])[CH3:1]

참가 물질

3

반응물 1

HCID 72172Ubenimex

생성물 1

HCID 6106L-Leucine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The hydrolysis of bestatin in 6 N HCl at 100° C. for 18 hours yields L-leucine and an unusual amino acid. The ratio of these amino acids is 1:1. Bestatin gives positive Rydon-Smith and ninhydrin reactions. The amino acid sequence of bestatin shown in the structure was elucidated by fragmentation pattern in mass spectrum of bestatin methyl ester hydrochloride. Thus, the structure of bestatin is (2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine.

출처 및 근거

ORD 기록
ord-40fb644ac47b47518b3d1cc593b69f10
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04179573

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