Sodium Hydroxide → HCID 20380421, 화합물

HRID 1448638노트

반응식

HRID 1448638 반응식
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10][C:11]1[C:12](=[O:16])[CH2:13][CH2:14][CH:15]=1)([O:3]C)=[O:2].[OH-].[Na+]>CO.O>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10][C:11]1[C:12](=[O:16])[CH2:13][CH2:14][CH:15]=1)([OH:3])=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 19607074Methyl 6-[(5-oxocyclopent-1-en-1-yl)sulfanyl]hexanoate

생성물 1

HCID 20380421HCID 20380421, 화합물수율 51.9%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

2-(5-Carbomethoxypentylthio)cyclopent-2-en-1-one (133 mg) was treated with 0.8 ml of a 3 N aqueous solution of sodium hydroxide in 5 ml of methanol and 2 ml of water at room temperature for 45 minutes. After the reaction, the reaction mixture was extracted with diethyl ether. The aqueous layer was acidified with hydrochloric acid, and extracted with diethyl ether. The extracts were treated in a customary manner to afford 125 mg of a crude product. The crude product was chromatographed on a thin layer plate with diethyl ether/isopropyl ether/acetic acid (=75/30/3) to afford 65 mg of 2-(5-carboxypentylthio)cyclopent-2-en-1-one in a yield of 49%. The product had the following characteristics.

후처리

  1. customAfter the reaction
  2. extractionthe reaction mixture was extracted with diethyl ether
  3. extractionextracted with diethyl ether
  4. additionThe extracts were treated in a customary manner
  5. customto afford 125 mg of a crude product
  6. customThe crude product was chromatographed on a thin layer plate with diethyl ether/isopropyl ether/acetic acid (=75/30/3)

출처 및 근거

ORD 기록
ord-8b6cb305f15d46079e63592f8605257b
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04180672

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