Hydrogen Bromide → L-alanyl-L-proline anilide hydrobromide

HRID 1448729노트

반응식

HRID 1448729 반응식
C(OC([NH:11][C@H:12]([C:14]([N:16]1[CH2:29][CH2:28][CH2:27][C@H:17]1[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:19])=[O:15])[CH3:13])=O)C1C=CC=CC=1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[NH2:11][C@H:12]([C:14]([N:16]1[CH2:29][CH2:28][CH2:27][C@H:17]1[C:18]([NH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])=[O:15])[CH3:13]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 35369893HCID 35369893, 화합물

생성물 1

HCID 22809936L-alanyl-L-proline anilide hydrobromide수율 83%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

10 g (0.025 mol) of N-benzyloxycarbonyl-L-alanyl-L-proline anilide were dissolved in 50 ml of 4-N hydrogen bromide in acetic acid and the solution was stirred at room temperature for 1 hour. 300 ml of dry ether were then added. An oil precipitated out and was allowed to settle. The solution was decanted off and the oil was washed with two 150 ml portions of ether, dissolved in the minimum volume of methanol and treated with an excess of ethyl acetate. The product soon crystallised, there being obtained 7.2 g (83%) of L-alanyl-L-proline anilide hydrobromide of melting point 211°-214° C.

후처리

  1. customAn oil precipitated out
  2. customThe solution was decanted off
  3. washthe oil was washed with two 150 ml portions of ether
  4. dissolutiondissolved in the minimum volume of methanol
  5. additiontreated with an excess of ethyl acetate
  6. customThe product soon crystallised

출처 및 근거

ORD 기록
ord-fbf6324716904fcfaaf80f7025b051f8
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04187216

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