Hydrogen Bromide → L-alanyl-L-proline cyclohexylamide hydrobromide

HRID 1448737노트

반응식

HRID 1448737 반응식
[CH:1]1([NH:7][C:8](=[O:29])[C@@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:14](=[O:28])[C@H:15]([CH3:27])[NH:16]C(OCC2C=CC=CC=2)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[CH:1]1([NH:7][C:8](=[O:29])[C@@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:14](=[O:28])[C@H:15]([CH3:27])[NH2:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 53880215HCID 53880215, 화합물

생성물 1

HCID 70586840L-alanyl-L-proline cyclohexylamide hydrobromide수율 100%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2 g (0.005 mol) of N-benzyloxycarbonyl-L-alanyl-L-proline cyclohexylamide were dissolved in 10 ml of 4-N hydrogen bromide in acetic acid and the mixture was stirred at room temperature for 1 hour. 100 ml of dry ether were then added. An oil precipitated and was allowed to settle. The solution was decanted off, the oil washed with 100 ml of ether, dissolved in the minimum volume of methanol and an excess of ethyl acetate added. Crystallisation soon took place and there were obtained 1.75 g (100%) of L-alanyl-L-proline cyclohexylamide hydrobromide of melting point 233°-236° C.

후처리

  1. customAn oil precipitated
  2. customThe solution was decanted off
  3. washthe oil washed with 100 ml of ether
  4. dissolutiondissolved in the minimum volume of methanol
  5. additionan excess of ethyl acetate added
  6. customCrystallisation soon took place

출처 및 근거

ORD 기록
ord-9077db9f20ed48fe81c39a06633bca84
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04187216

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