Diethyl Ether → L-alanyl-L-proline n-pentylamide

HRID 1448745노트

반응식

HRID 1448745 반응식
[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH:15]C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][CH2:4][CH3:5].CCOCC>Br.C(O)(=O)C>[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH2:15])[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 2

HCID 3283Diethyl EtherHCID 53667817HCID 53667817, 화합물

생성물 1

HCID 54383360L-alanyl-L-proline n-pentylamide수율 152.5%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

실험 절차

2.5 g of N-benzyloxycarbonyl-L-alanyl-L-proline n-pentylamide were dissolved in 15 ml of 4-N hydrogen bromide in acetic acid and the solution was stirred for 1 hour at room temperature. 150 ml of dry ether were added. An oil precipitated out and was allowed to settle. The ether was decanted off and the procedure repeated using 150 ml of fresh ether. On evaporation there were obtained 2.5 g of L-alanyl-L-proline n-pentylamide in the form of a white solid.

후처리

  1. customAn oil precipitated out
  2. customThe ether was decanted off
  3. customOn evaporation there

출처 및 근거

ORD 기록
ord-f1c080d621b844b1b64286a577ad7823
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04187216

반응 노트

불러오는 중…