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Hydrochloric Acid → HCID 131711714, 화합물

HRID 1448775
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HRID 1448775 반응식
Cl.[NH:2]([C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[C@H:3]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:25]([NH:27][CH2:28][C:29]([NH:31]N)=[O:30])=[O:26])[CH2:23][OH:24])=[O:20])[CH3:18])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.N[C@H:44]([CH2:49][OH:50])[CH2:45][C:46](=[O:48])[NH2:47].C(N(CC)CC)C>O1CCOCC1.N(OC(C)(C)C)=O.CN(C=O)C.C(OCC)(=O)C>[NH:2]([C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[C@H:3]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:25]([NH:27][CH2:28][C:29]([NH:31][C@H:44]([CH2:49][OH:50])[CH2:45][C:46](=[O:48])[NH2:47])=[O:30])=[O:26])[CH2:23][OH:24])=[O:20])[CH3:18])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

9

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 3082455AsparaginolHCID 131711715HCID 131711715, 화합물

생성물 1

HCID 131711714HCID 131711714, 화합물

시약·촉매·용매 4

HCID 6228Dimethylformamide용매
HCID 8857
Ethyl Acetate
용매
HCID 10906Tert-Butyl nitrite용매
HCID 312751,4-Dioxane용매

실험 절차

2.9 ml of 5.6 N HCl in dioxan and 0.67 ml of tert. butyl nitrite are added at -20° to a solution of 3.2 g of Z-Trp-Ala-Ser-Gly-NHNH2 in 50 ml of DMF. After standing 15 minutes at -20° 1.89 of L-Asparaginol hydrochloric and 2.5 ml of triethylamine are added. After standing for 15 hours at room temperature the reaction mixture is considerably reduced in volume, diluted with ethyl acetate and washed with dilute aqueous hydrochloride acid and with water. The title compound precipitates from the concentrated solution.

후처리

  1. waitAfter standing for 15 hours at room temperature
  2. washwashed with dilute aqueous hydrochloride acid and with water
  3. customThe title compound precipitates from the concentrated solution

출처 및 근거

ORD 기록
ord-e30be469581b413b98346acc682ad5bd
출처 데이터셋
uspto-grants-1980_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04187295

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