Hydrochloric Acid → 7,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one

HRID 14489

반응식

HRID 14489 반응식
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=[C:8]([CH:15]([CH3:17])[CH3:16])[O:9]2)=[CH:4][CH:3]=1.Cl>CO.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)=[C:8]([CH:15]([CH3:16])[CH3:17])[O:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 597242787-Amino-3-(4-chlorophenyl)-2-isopropyl-8-nitro-chromen-4-one

생성물 1

HCID 687024427,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

7-Amino-3-(4-chlorophenyl)-2-isopropyl-8-nitro-chromen-4-one (450 mg, 0.94 mmol) is suspended in methanol (5 ml). Concentrated hydrochloric acid (5 ml) is added. The mixture is placed under an atmosphere of argon, and 10% palladium on activated carbon (50 mg) is added. The reaction mixture is placed under an atmosphere of hydrogen and stirred at room temperature for 24 h. The mixture is filtered through a Celite pad, and the Celite pad is washed with methanol (3×30 ml). The filtrate and the washings are combined and evaporated to give a yellow solid.

후처리

  1. filtrationThe mixture is filtered through a Celite pad
  2. washthe Celite pad is washed with methanol (3×30 ml)
  3. customevaporated
  4. customto give a yellow solid

출처 및 근거

ORD 기록
ord-0189d225b5614d789f5d04eee4b24eaf
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732435B2

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