Methyl iodide → Oxoglaucine methiodide

HRID 1448957노트

반응식

HRID 1448957 반응식
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]2[C:15]3[C:20]([C:21](=[O:22])[C:9]4=[C:10]2[C:5](=[CH:6][CH:7]=[N:8]4)[CH:4]=1)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3.[I:27][CH3:28]>CC(C)=O>[CH3:28][N+:8]1[CH:7]=[CH:6][C:5]2[C:10]3=[C:11]([C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[C:15]2[C:20]([C:21](=[O:22])[C:9]=13)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=2.[I-:27]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 97662Oxoglaucine2회

생성물 1

HCID 41680Oxoglaucine methiodide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Oxoglaucine methiodide was prepared from oxoglaucine in accordance with the process of Example V. A 31 mg sample of oxoglaucine was refluxed in 8 ml of acetone until it completely dissolved (approximately 30 minutes) and then 0.75 ml of iodomethane was added. The solution was refluxed until it became brown. The crystals were then collected by filtration to yield 15 mg of the methiodide salt, mp 255 d.

후처리

  1. dissolutioncompletely dissolved (approximately 30 minutes)
  2. temperatureThe solution was refluxed until it
  3. filtrationThe crystals were then collected by filtration

출처 및 근거

ORD 기록
ord-5a9774a886b6439abe3ac74e8399998a
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188392

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