Ethanol → 4,5-bis-(4-bromophenyl)-1H-imidazole-2-thione

HRID 1448983노트

반응식

HRID 1448983 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)O)=O)=[CH:4][CH:3]=1.[NH2:19][C:20]([NH2:22])=[S:21].O.C(O)C>C(O)CCCCC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:19][C:20](=[S:21])[NH:22][C:10]=2[C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 962WaterHCID 2723790ThioureaHCID 39382431,2-Bis(4-bromophenyl)-2-hydroxyethanone

생성물 1

HCID 35546154,5-bis-(4-bromophenyl)-1H-imidazole-2-thione

시약·촉매·용매 1

HCID 81031-Hexanol용매

실험 절차

A mixture of 4,4'-dibromobenzoin (25 g, 0.068 mol) and thiourea (10.3 g, 0.14 mol) in hexanol (200 ml) was refluxed with azeotropic distillation of water for three hours. The solution was then cooled and ethanol (300 ml) was added. The mixture was further cooled and the small needles which formed were collected and washed with cold ethanol then ether and dried. Recrystallization of the product from ethyl acetate gave 4,5-bis-(4-bromophenyl)-1H-imidazole-2-thione, m.p. 288°.

후처리

  1. temperatureThe solution was then cooled
  2. temperatureThe mixture was further cooled
  3. customthe small needles which formed
  4. customwere collected
  5. washwashed with cold ethanol
  6. dry with materialether and dried
  7. customRecrystallization of the product from ethyl acetate

출처 및 근거

ORD 기록
ord-923517e0f45c4bbea8b8ddf7c9c5cb19
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188397

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