Water → HCID 13507961, 화합물

HRID 1448985노트

반응식

HRID 1448985 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)O)=O)=[CH:5][CH:4]=1.[NH2:25][C:26]([NH2:28])=[S:27].O>CN(C)C=O>[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:25][C:26](=[S:27])[NH:28][C:11]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 2723790ThioureaHCID 15044210HCID 15044210, 화합물

생성물 1

HCID 13507961HCID 13507961, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4,4'-di(trifluoromethyl)benzoin (50 g, 0.15 mol) and thiourea (15.2 g, 0.2 mol) in dimethylformamide (350 ml) was refluxed under argon for three hours. The cooled solution was poured into 1 liter of water and the resulting solid was collected, washed with water, air-dried and recrystallized from ethanol to give 4,5-bis-(4-trifluoromethylphenyl)-1H-imidazole-2-thione, m.p. 312°-315°.

후처리

  1. temperaturewas refluxed under argon for three hours
  2. customthe resulting solid was collected
  3. washwashed with water
  4. customair-dried
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-a63b6b8564dc4b17bfcc1c173d3330ab
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188397

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