Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → 2-Phthalimidomethyl-6-methyl-4-(phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 반응물 | Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate | HCID 701239 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Phthalimidomethyl-6-methyl-4-(phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70588903 | 75% |
반응 단계
A solution of 10.6 g of benzaldehyde, 28 g of phthalimidoacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 150 ccs of ethanol is heated under reflux for 2×24 hours, the mixture is stirred overnight at room temperature and the precipitate is filtered off and washed with alcohol and ether. Light yellow crystals of melting point 169°-170° C. are obtained in 75% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04188395 |
| 출처 데이터셋 | uspto-grants-1980_02 |
| ORD ID | ord-373602fb6c314dc180d17ff52bea214b |
| 출처 메모 | uspto-grants-1980_02 |