反应详情

A solution of 10.6 g of benzaldehyde, 28 g of phthalimidoacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 150 ccs of ethanol is heated under reflux for 2×24 hours, the mixture is stirred overnight at room temperature and the precipitate is filtered off and washed with alcohol and ether. Light yellow crystals of melting point 169°-170° C. are obtained in 75% yield.

1. temperatureunder reflux for 2×24 hours
2. filtrationthe precipitate is filtered off
3. washwashed with alcohol and ether
4. customLight yellow crystals of melting point 169°-170° C. are obtained in 75% yield