Ethanol → 1,2-Benzisothiazol-4-ol, 7-amino-

HRID 1449115노트

반응식

HRID 1449115 반응식
CO.C(O)C.C(OC(=O)C)(=O)C.[NH:13]([C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([O:26]C(=O)C)=[CH:19][CH:18]=1)C(C)=O>C(O)(=O)C.C(O)CC>[NH2:13][C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([OH:26])=[CH:19][CH:18]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 887MethanolHCID 7918Acetic AnhydrideHCID 203499417-Acetamino-4-acetoxy-1,2-benzisothiazole2회

생성물 1

HCID 1356171871,2-Benzisothiazol-4-ol, 7-amino-

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 10311-Propanol용매

실험 절차

This reduction is as a rule carried out under atmospheric pressure or in a closed vessel under superatmospheric pressure, with or without simultaneous heating. The reaction may be carried out in the presence of a diluent or solvent, for example, a lower alcohol, e.g. methanol, ethanol or preferably propanol, or in the acid required for the reduction, preferably in acetic acid, or in the acylating reaction medium of acetic acid and acetic anhydride, described above, in which 7-acetamino-4-acetoxy-1,2-benzisothiazole is obtained. 7-Acetamino-4-acetoxy-1,2-benzisothiazole can subsequently be deacylated in the above manner to give 7-amino-4-hydroxy-1,2-benzisothiazole.

후처리

  1. customcarried out under atmospheric pressure or in a closed vessel under superatmospheric pressure
  2. customThe reaction
  3. customis obtained

출처 및 근거

ORD 기록
ord-38f6917caac942a9a95e10acc735d2e3
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04189433

반응 노트

불러오는 중…