Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Ibuprofen, (+-)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Ibuprofen, Sodium Salt | HCID 5338317 | — |
| 생성물 | Ibuprofen, (+-)- | HCID 3672 | 93.2% |
반응 단계
The aqueous basic fraction containing sodium ibuprofen salt was acidified with 6N sulfuric acid, sodium chloride was added, and then extracted twice with Skellysolve B to take up the ibuprofen acid product therein. The Skellysolve B phase was dried over sodium sulfate and evaporated to leave as residue 867.7 mg. (93.2 percent yield) of ibuprofen which was 99.9 percent pure by gas liquid chromatographic (GLC) analysis.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04189596 |
| 출처 데이터셋 | uspto-grants-1980_02 |
| ORD ID | ord-9fb0f63a25da4ea98b6394c83ae0b917 |
| 출처 메모 | uspto-grants-1980_02 |