反应详情

The aqueous basic fraction containing sodium ibuprofen salt was acidified with 6N sulfuric acid, sodium chloride was added, and then extracted twice with Skellysolve B to take up the ibuprofen acid product therein. The Skellysolve B phase was dried over sodium sulfate and evaporated to leave as residue 867.7 mg. (93.2 percent yield) of ibuprofen which was 99.9 percent pure by gas liquid chromatographic (GLC) analysis.

1. additionwas added
2. extractionextracted twice with Skellysolve B
3. dry with materialThe Skellysolve B phase was dried over sodium sulfate
4. customevaporated
5. customto leave as residue 867.7 mg