Hydrochloric Acid → 2-(2-Indenyl)-3-methylbutanoic acid

HRID 1449228노트

반응식

HRID 1449228 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([O:13]CC1C=CC=C(OC2C=CC=CC=2)C=1)=[O:12].[OH-].[K+].C(O)C.Cl>O>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:1]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([OH:13])=[O:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 13146349m-Phenoxylbenzyl 2-(2-indenyl)-3-methylbutanoate

생성물 1

HCID 233470912-(2-Indenyl)-3-methylbutanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of m-phenoxylbenzyl 2-(2-indenyl)-3-methylbutanoate (8 mmol), potassium hydroxide (24 mmol), ethanol (25 ml) and water (4 ml) is heated to reflux for about 3 hours. After cooling, the reaction is acidified with dilute hydrochloric acid. The mixture is extracted with ether, and the ether phase is washed to neutrality with saturated NaCl solution. Removal of solvent by evaporation yields 2-(2-indenyl)-3-methylbutanoic acid.

후처리

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperatureAfter cooling
  4. extractionThe mixture is extracted with ether
  5. washthe ether phase is washed to neutrality with saturated NaCl solution
  6. customRemoval of solvent
  7. customby evaporation

출처 및 근거

ORD 기록
ord-45b060fe13b245248a2d3e41a7f388b2
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04189598

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