Acetone → HCID 12946261, 화합물

HRID 1449379노트

반응식

HRID 1449379 반응식
[CH3:1][C:2](C)=[O:3].[F:5][C:6]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:11]([OH:12])[NH:10][C:9](=[O:13])[NH:8][C:7]1=[O:14].C(OC(=O)C)(=O)C>N1C=CC=CC=1>[C:2]([O:12][CH:11]1[NH:10][C:9](=[O:13])[NH:8][C:7](=[O:14])[C:6]1([F:5])[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:3])[CH3:1]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 7918Acetic AnhydrideHCID 12901279HCID 12901279, 화합물

생성물 1

HCID 12946261HCID 12946261, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In 10 ml. of acetone was dissolved 8.80 g. (40 m moles) of ethyl 5-fluoro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate, and under ice-cooling, 5.10 g. (50 m moles) of acetic anhydride and 10 ml. of pyridine were added. The mixture was reacted at room temperature overnight. (A sample of the reaction mixture was taken, the solvent was distilled off under reduced pressure and the NMR spectrum of the residue was measured to ensure that there had been produced ethyl 6-acetoxy-5-fluoro-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate

후처리

  1. customThe mixture was reacted at room temperature overnight
  2. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-1d038a9ebab942a190abfc3ea848bdb0
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04190656

반응 노트

불러오는 중…